| Dimethyl pimelimidate | |
|---|---|
|
Dimethyl heptanediimidate |
|
|
Other names
Pimelimidic acid dimethyl ester dihydrochloride, |
|
| Identifiers | |
| CAS number | 36875-25-9, 58537-94-3 (dihydrochloride) |
| PubChem | 65403 |
| ChemSpider | 16742681 |
| Jmol-3D images | Image 1 |
|
|
| Properties | |
| Molecular formula | C9H18N2O2 |
| Molar mass | 186.25 g mol−1 |
| Appearance | White crystalline powder (dihydrochloride) |
| Melting point |
122 °C, 395 K, 252 °F (dihydrochloride) |
| Solubility in water | Slightly soluble (dihydrochloride) |
| Hazards | |
| NFPA 704 |
1
1
0
|
| Flash point | Not determined |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Dimethyl pimelimidate (DMP) is an organic chemical compound with two functional imidate groups. It is usually available as the more stable dihydrochloride salt. It binds free amino groups at pH range 7.0-10.0 to form amidine bonds.
DMP is used mainly as bifunctional coupling reagent to link proteins. It is often used to prepare antibody affinity columns. The appropriate antibody is first incubated with Protein A or Protein G-agarose and allowed to bind. DMP is then added to couple the molecules together.
DMP is irritating to the eyes, skin, mucous membranes and upper respiratory tract. It can exert harmful effects by inhalation, ingestion, or skin absorption.